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. 2018 Nov 26;221(23):jeb185504. doi: 10.1242/jeb.185504

Fig. 3.

Fig. 3.

Blocking the actions of glucocorticoids does not ameliorate the effects of LPS on testosterone. (A) Animals pre-treated with mifepristone (RU-486) showed increases in serum LH after kisspeptin injection, regardless of LPS treatment. (B) Despite pre-treatment with mifepristone, LPS significantly attenuated the gonadal response to kisspeptin, similar to experiment 1. Boxes denote the boundaries of the second and third quartiles with Tukey whiskers. Asterisks denote significant differences between pre- and post-injection time points. Significance was set at P<0.05 (***P<0.001). Plus signs indicate the group mean, while circles and squares represent individual values falling within 1.5 times the interquartile range of the distribution of the pre- or post-injection time points. Letters denote differences between groups at the post-injection time point. For LH graph, oil+saline+PBS, n=11; oil+LPS+PBS, n=12; oil+ saline+kisspeptin, n=12; oil+LPS+kisspeptin, n=12; mifepristone+saline+PBS, n=10; mifepristone+LPS+PBS, n=10; mifepristone+saline+kisspeptin, n=10; mifepristone+LPS+kisspeptin, n=9. Group sizes for testosterone graph in B (because of missing values): n=10 for all groups except oil+saline+PBS, n=8; oil+saline+kisspeptin, n=11; mifepristone+LPS+kisspeptin, n=9.