Table 3.
Chromatin enrichment
| Cell type | Annotation | P value | Δenrichment |
|---|---|---|---|
| Melanocyte | H3K27ac | NS | 0.00317 |
| H3K27me3 | NS | 0.00460 | |
| H3K36me3 | NS | −0.00576 | |
| H3K4me1 | NS | −0.02505 | |
| H3K4me3 | 0.00054 | 0.01526 | |
| H3K9me3 | 0.00054 | 0.00921 | |
| DHS | NS | −0.01382 | |
| TSS | NS | −0.00259 | |
| MITF | 0.0009 | 0.01497 | |
| Keratinocyte | H3K27ac | NS | 0 |
| H3K27me3 | 0.0453 | 0.00749 | |
| H3K36me3 | NS | −0.02160 | |
| H3K4me1 | NS | 0.00605 | |
| H3K4me3 | <10−4 | 0.02418 | |
| H3K9me3 | NS | −0.01785 | |
| TSS | NS | −0.00432 | |
| Fibroblast | H3K27ac | NS | 0.00346 |
| H3K27me3 | <10−4 | 0.02246 | |
| H3K36me3 | NS | 0.00461 | |
| H3K4me1 | NS | −0.01180 | |
| H3K9me3 | 0.0038 | 0.00720 | |
| DHS | NS | −0.02332 | |
| Iris pigment | TSS | <10−4 | 0.00519 |
| Dermal fibroblast | TSS | NS | −0.00259 |
| Skin fibroblast | TSS | NS | −0.00086 |
| Skin tissue | TSS | NS | −0.00375 |
| Embryoid melanocytic induction | TSS | NS | −0.00230 |
| Hermes3A | MITF | NS | −0.00374 |
Enrichment for cell type-specific annotations, using GWAS loci from all hair colours. The Δenrichment column represents the change in enrichment (nsnpOverlap/allsSnps) between our dataset and the median of the 10,000 permutations