Table 5.
Comparison of patients with hypertension in quartile 1 versus quartiles 2–4 of delta mean arterial pressure (n = 153)
| Characteristic | First quartile (n = 39) | Second to fourth quartiles (n = 114) | p value |
|---|---|---|---|
| Age, median (IQR), year | 73.7 (55.9–80.7) | 74.8 (64.2–83.1) | .14 |
| Body mass index, median (IQR), kg/m2 | 28.6 (23.9–34.1) | 27.9 (23.3–33.6) | .39 |
| Male sex, No. (%) | 22 (56.4) | 61 (53.5) | .85 |
| Pre-admission MAP, median (IQR), mmHga | 75.0 (69.0–84.0) | 83.5 (76.7–91.3) | .01 |
| Post-resuscitation MAP, median (IQR), mmHgb | 79.0 (71.5–86.0) | 65.0 (61.0–70.3) | .01 |
| Acute kidney injury, No. (%) | 24 (61.5) | 91 (79.8) | .03 |
| Stage 1 | 9 (18.8) | 39 (81.3) | |
| Stage 2 | 10 (23.8) | 32 (76.2) | |
| Stage 3 | 5 (20.0) | 20 (80.0) | |
| Charlson comorbidity index, median (IQR) | 9 (6–12) | 7.5 (6–11) | .62 |
| APACHE III score, day 1, median (IQR) | 88 (72–99) | 85.5 (68.8–104.3) | .51 |
| SOFA score, day 1, median (IQR) | 6 (4–8) | 7 (4–10) | .28 |
| Preexisting condition, No. (%) | |||
| Myocardial infarction | 10 (25.6) | 31 (27.2) | > .99 |
| Congestive heart failure | 14 (35.9) | 25 (21.9) | .09 |
| Peripheral vascular disease | 5 (12.8) | 22 (19.3) | .47 |
| Dementia | 0 (0) | 10 (8.8) | .07 |
| Cerebrovascular accident | 8 (20.5) | 28 (24.6) | .67 |
| Chronic pulmonary disease | 12 (30.8) | 40 (35.1) | .70 |
| Rheumatic heart disease | 6 (15.4) | 10 (8.8) | .24 |
| Diabetes mellitus | 18 (46.2) | 48 (42.1) | .71 |
| Peptic ulcer disease | 6 (15.4) | 18 (15.8) | > .99 |
| Cirrhosis | 0 (0) | 8 (7.0) | .20 |
| Hemiplegia | 5 (12.8) | 2 (1.8) | .01 |
| Kidney disease | 13 (33.3) | 35 (30.7) | .84 |
| Brittle diabetes mellitus | 7 (17.9) | 20 (17.5) | > .99 |
| Cancer | 15 (38.5) | 36 (31.6) | .44 |
| Leukemia | 2 (5.1) | 4 (3.5) | .65 |
| Lymphoma | 4 (10.3) | 3 (2.6) | .07 |
| Moderate or severe liver disease | 0 (0) | 4 (3.5) | .57 |
| Metastatic cancer | 5 (12.8) | 10 (8.8) | .53 |
| Any inotropic agent, No. (%) | 3 (7.7) | 21 (18.4) | .13 |
| Any vasoactive agent, No. (%) | 24 (61.5) | 70 (61.4) | > .99 |
| Fluid balance, median (IQR), mL | 7193 (1349–10,280) | 5733 (2820–10,220) | .32 |
ΔMAP is defined as pre-admission minus post-resuscitation MAP
APACHE acute physiology, age, chronic health evaluation, MAP mean arterial pressure, SOFA sequential organ failure assessment
aFrom noninvasive blood pressure monitoring
bSeventh hour of early goal-directed therapy