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. 2018 Dec 10;8:17747. doi: 10.1038/s41598-018-35807-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of changes in mouse plasma lipids with age. (A) Schematic illustration of sample collection. (B) Boxplot showing the distribution of total plasma lipid content and different lipid classes in young and old mice. *P < 0.05, ns: Not Significant. (C) Pie chart depicting the proportion of detected lipids that are significantly increased (red), decreased (blue) or do not change (grey) with age (FDR < 0.05). (D) Pie chart showing the proportion of different classes that change with age. (E) Venn diagram representing the overlap of deregulated lipids detected with the LC-MS and Lipidyzer platforms. TAG were excluded from this analysis because of nomenclature discrepancies between the two approaches. (F) Proportion and number of deregulated lipids within each class. TAG: triacylglycerol, DAG: diacylglycerol, PC: phosphatidylcholine, PE: phosphatidylethanolamine, PI: phosphatidylinositol, LPC: lysophosphatidylcholine, LPE: lysophoshatidylethanolamine, SM: sphingomyelin, CER: ceramide, CE: cholesterol ester, FFA: free fatty acid, MISC: miscellaneous.