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. 2018 Dec 10;8:17759. doi: 10.1038/s41598-018-36009-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative multiphoton images of ex vivo human skin at different depths at 5, 13, 23 and 33 minutes post Nanopatch application onto the skin. The Nanopatch was coated with (a) 70 kDa (b) 500 kDa and (c) 2000 kDa rhodamine-labelled dextran, applied onto the skin using a spring-loaded applicator and left on the skin for 2 minutes to allow sufficient time for coating dissolution and approximately 3 minutes for excision and loading of the specimen onto the microscope stage and initialising it before the first images were captured. All images were pseudocoloured to highlight rhodamine-dextran (magenta) and skin (green) emissions.