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. 2018 Dec 4;9:513. doi: 10.3389/fgene.2018.00513

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Copyright © 2018 Spence, Reiter, Qiu, Gu, Garcia, Zhang, Graves, Williams, Bice, Zou, Lai, Yong and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Adcyap1r1 expression is increased in female ISCS-B relative to iP rats. (B) Male ISCS-B rats demonstrate no significant difference from iP in Adcyap1r1 expression. (C) A schematic of the Adcyap1r1 promoter sequence demonstrating ER binding sites and polymorphisms between iP and iNP. (D) ERα transactivation of both variants of the Adcyap1r1 promoter enhanced luciferase activity, but the iNP promoter exhibited significantly more luciferase activity than iP.