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. 2018 Dec 4;9:1423. doi: 10.3389/fphar.2018.01423

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Copyright © 2018 Huang, Lan, Lu, Zhang, Zhang, Lou, Xu, Ren, Zhao, Sun, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of DDT on OGD-induced intracellular mitochondrial damage in NGF-induced PC12 cells. (A) After treatment with DDT prior to OGD for 1.5 h, PC12 cells were incubated with a JC-1 probe to assess mitochondrial membrane potential (MMP) by FCM. (B) Bar graph represents the cells positive for JC-1 monomer analyzed from (A). (C) MMP of PC12 cells treated with DDT for 48 h and incubated with OGD for 1.5 h was monitored by measuring fluorescence intensity. (D) After pretreatment with DDT at different concentrations for 48 h and OGD incubation for 1.5 h, the levels of Cyto C, p-Bad and Bad in PC12 cells were detected by Western blot. ^∗P < 0.05 and ^∗∗∗P < 0.001 vs. Ctrl group; ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 vs. OGD group (n = 3).