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. 2018 Dec 4;9:2846. doi: 10.3389/fimmu.2018.02846

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Copyright © 2018 Bruijnesteijn, van der Wiel, de Groot, Otting, de Vos-Rouweler, Lardy, de Groot and Bontrop.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suboptimal splice sites might mediate the skipping of exon 7 in KIR2DL4, KIR2DL5, and KIR3DL2 transcripts. Exon 7 is indicated in gray boxes, whereas the BPS and PPT elements are indicated in blue and red boxes, respectively. The 3′ ss region (3′ ss and PPT) and the 5′ ss sequences of lineage III KIR genes, except for KIR2DL1/2, are used as consensus sequences. Dashes (-) indicate sequence identity with the consensus sequence. The splicing strength scores of the 3′ and 5′ splice sites are provided. The BPS and 3′ splice sites of exon 7 were identical, but variation was observed in the PPT and 5′ splice site.