Figure 9.

Alternative splice sites in intron 7 of Mamu-KIR2DL04. Transcripts are illustrated with the exons indicated in blue boxes, and corresponding protein structures are schematically depicted adjacent to the transcript. Intronic inclusions are indicated in gray boxes, and stopcodons are marked by a black box with asterisk (*). Splice events are indicated with dashed lines. Three alternative 3′ splice sites were identified in intron 7 of Mamu-KIR2DL04, and result in intron inclusions of 109, 147, and 245/246 bp subsequent to exon 7. All these inclusions result in a frameshift that introduces a stopcodon, indicating membrane-bound KIR2D receptors without an inhibitory cytoplasmic tail.