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. 2018 Dec 4;5:340. doi: 10.3389/fmed.2018.00340

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Copyright © 2018 Magro-Checa, Steup-Beekman, Huizinga, van Buchem and Ronen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basis of Magnetization Transfer Imaging. (A) This technique is based on the application of off-resonance radiofrequency pulses. M₀: proton density image or intensity of voxels without saturation, M_s: Bound protons or intensity of voxels saturated. (B) Measurement of signal intensity with and without the application of these pulses allows the calculation of an index called the magnetization transfer ratio (MTR) which is defined as (M₀-M_s/M₀) × 100%. (C) MTR histogram: this technique takes a ratio of the two images on a voxel-by-voxel basis (brain pixels). (D) The histogram peak height (HPH), a MTR histogram-derived measure, accounts for the proportion of brain pixels at the most common MTR value. (A) partially adapted from Grossman et al. (61).