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. 2018 Dec 4;12:893. doi: 10.3389/fnins.2018.00893

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Copyright © 2018 Ojo, Algamal, Leary, Abdullah, Mouzon, Evans, Mullan and Crawford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arachidonic acid and docosahexaenoic acid containing phospholipid species in the hippocampus of repetitive mTBI hTau mice. Significant changes in arachidonic acid and docosahexaenoic acid containing PI (A,B), PE (C,D), PC (E,F), and LPC (G,H) species in the hippocampus of a model of repetitive-mTBI in hTau mice. Sample size for all groups across all time points is n = 4. Data represent mean μmol per wet weight (5.5 mg) ±SEM. Individual molecular lipid species were quantified by liquid chromatography/mass spectrometry and were summed after LipidomeDB analyses to generate arachidonic and decosahexaenoic acid levels for each phospholipid species. Asterisks represent ⁺P < 0.05, ⁺⁺P < 0.01, ⁺⁺⁺P < 0.001 for comparisons between sham/r-mTBI mice. PE, phosphatidylethanolamine; PC, phosphatidylcholine; PI, phosphatidylinositol; LPC, lysophosphatidylcholine.