Table 4.
Monounsaturated fatty acid containing phospholipid species in the cortex of repetitive mTBI hTau mice.
| Monounsaturated fatty acid containing lipid species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Phosphatidylcholine (PC) | Phosphatidylethanolamine (PE) | Phosphatidylinositol (PI) | Sphingomyelin (SM) | ||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | ||
| SHAM | 24H | 63.673 | 4.493 | 8.923 | 0.544 | 5.522 | 0.933 | 1.024 | 0.093 |
| 3M | 61.204 | 4.354 | 8.723 | 0.289 | 6.531 | 1.065 | 1.673 | 0.114 | |
| 6M | 82.151 | 7.063 | 10.935 | 0.767 | 7.120 | 1.100 | 2.272 | 0.112 | |
| 9M | 74.872 | 5.334 | 10.827 | 0.472 | 6.733 | 1.094 | 1.910 | 0.076 | |
| 12M | 76.644 | 5.844 | 11.771 | 0.578 | 6.691 | 1.021 | 2.009 | 0.099 | |
| r-mTBI | 24H | 88.344+ | 8.963 | 12.035+ | 0.761 | 7.443 | 1.241 | 1.509+ | 0.073 |
| 3M | 69.087 | 6.618 | 9.672 | 0.694 | 6.402 | 1.099 | 2.051+ | 0.134 | |
| 6M | 73.181 | 4.264 | 10.459 | 0.516 | 7.099 | 1.217 | 2.364 | 0.193 | |
| 9M | 84.734 | 5.944 | 11.883 | 0.468 | 7.385 | 1.191 | 2.165 | 0.079 | |
| 12M | 74.950 | 4.091 | 11.173 | 0.534 | 6.943 | 1.207 | 2.049 | 0.131 | |
Significant changes in monounsaturated fatty acid containing PC, PE, PI, and SM species in the hippocampus of repetitive mTBI hTau mice. Sample size for all groups across all time points is n = 4. All data represent mean μM per (5.5 mg) wet weight ±SEM. Individual molecular lipid species were quantified by liquid chromatography/mass spectrometry and were summed after LipidomeDB analyses to generate monounsaturated fatty acid classification for each phospholipid species was compiled from these values. Asterisks represent +P < 0.01 for comparisons between sham/r-mTBI mice. PE, phosphatidylethanolamine; PC, phosphatidylcholine; PI, phosphatidylinositol; SM, sphingomyelin.