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. 2018 Dec 4;9:1389. doi: 10.3389/fphar.2018.01389

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Copyright © 2018 She, Ma, Liu, Zhang, Qiu, Chen, Li, Xue, Luo, Wang, Xu, Zang, Zhao, Cao, Shen, Peng, Zhao, Yu, Chen, Nie, Shen, Chen, Chen, Qin, Dai, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EESC blocks contraction in mouse TRs. (A) ACh (100 μM) induced a sustained contraction in a mouse TR, which was blocked by EESC. The dose-inhibition curve is presented. (B) Similar experiments were performed, except that the TR contraction was induced by 80 mM K⁺. (C,D) The same experiments as above performed in epithelia-denuded TRs. These data indicate that the EESC blocks ASM contraction.