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. 2018 Dec 4;9:1389. doi: 10.3389/fphar.2018.01389

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Copyright © 2018 She, Ma, Liu, Zhang, Qiu, Chen, Li, Xue, Luo, Wang, Xu, Zang, Zhao, Cao, Shen, Peng, Zhao, Yu, Chen, Nie, Shen, Chen, Chen, Qin, Dai, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pyr3 inhibits ASM contraction. ACh induced a sustained contraction in a TR in the presence of nifedipine, which was inhibited by Pyr3 and the remainder was blocked by EESC. This experiment was performed in 6 TRs. These data indicate that EESC-induced relaxation is partially due to the inhibition of Pyr3 sensitive channels.