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. 2018 Dec 4;9:1389. doi: 10.3389/fphar.2018.01389

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Copyright © 2018 She, Ma, Liu, Zhang, Qiu, Chen, Li, Xue, Luo, Wang, Xu, Zang, Zhao, Cao, Shen, Peng, Zhao, Yu, Chen, Nie, Shen, Chen, Chen, Qin, Dai, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aurantio-obtusin inhibits ion channel-mediated currents in single tracheal smooth muscle cells. (A) LVDCC-mediated currents were recorded using the voltage steps (top). The representative traces show that the currents are blocked by nifedipine and aurantio-obtusin (middle). The current-voltage curves were plotted (bottom), showing that the currents were completely blocked by nifedipine and markedly inhibited by aurantio-obtusin. ^∗P < 0.05; ^∗∗∗P < 0.0001. (B) ACh-induced currents were recorded using a ramp (top). The non-selective cation channel (NSCC)-mediated currents are isolated in the presence of three blockers. The currents at -70 mV were used to construct time-current traces, showing that aurantio-obtusin and YM-58483 completely and Pyr3 greatly inhibited the currents. These results suggest that aurantio-obtusin inhibits nifedipine-, YM-58483- and Pyr3-senstive ion channels.