Table 1.
Baseline characteristics of MCs, aMCs, sMCs, and NMCs
| Characteristics | MC (N = 293) | aMC (N = 186) | sMC (N = 107) | NMC (N = 188) |
|---|---|---|---|---|
| Female, N (%) | 161 (55.0) | 106 (57.0) | 55 (51.4) | 112 (60.0) |
| Age (y), mean (SD) | 38.57 (11.04) | 34.01 (8.81) | 46.48 (10.04) | 38.29 (11.59) |
| Education (y), mean (SD) | 14.28 (3.02) | 14.78 (2.86) | 13.42 (3.1) | 14.73 (2.93) |
| Apolipoprotein E ε4 carrier, N (%) | 88 (30.0) | 54 (29.0) | 34 (31.8) | 59 (31.4) |
| CSF Aβ42 (pg/mL), mean (SD) | 892.97 (576.52) | 1069.9 (601.2) | 533.82 (287.24) | 1248.82 (440.18) |
| CSF total tau (pg/mL), mean (SD) | 288.58 (164.47) | 228.77 (102.37) | 409.97 (197.55) | 173.26 (58.91) |
| CSF Ptau181 (pg/mL), mean (SD) | 30.7 (23.22) | 21.44 (13.65) | 49.49 (27.09) | 14.28 (5.15) |
| Amyloid PIB PET global SUVR, mean (SD) | 1.97 (1.03) | 1.65 (0.77) | 2.76 (1.16) | 1.06 (0.15) |
| FDG PET global SUVR, mean (SD) | 1.68 (0.17) | 1.73 (0.14) | 1.58 (0.19) | 1.71 (0.14) |
| Hippocampal volume (mm3), mean (SD) | 4194.44 (642.22) | 4439.5 (484.65) | 3709.84 (642.37) | 4398.93 (404.26) |
| DIAN cognitive composite, mean (SD) | -0.61 (1.05) | -0.06 (0.61) | -1.68 (0.89) | -0.03 (0.62) |
Abbreviations: DIAN, Dominantly Inherited Alzheimer Network; MC, mutation carrier; aMC, asymptomatic MC; sMC symptomatic MC; NMC, mutation noncarrier; SUVR, standard uptake value ratio.