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. 2018 Nov 6;11:109–121. doi: 10.1016/j.omto.2018.10.005

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Replication-Incompetent Virus Induces Growth Control Also in the Non-injected Tumor at an Early Time Point

The sizes of injected (A and C) and non-injected (B and D) B16-OVA tumors in mice on day 8 (n = 3–8) without T cell transfer (A and B) or with OT-I cells (C and D) were compared with average mock tumor size on the same time point. Similar results were obtained for injected (E) and non-injected (F) tumors when the experiment was repeated. Viral DNA was detected only in the injected tumors (G). The bars show mean plus SEM. Statistical significance was evaluated with 2-way ANOVA: ****p < 0.0001; ***p < 0.001; *p < 0.05.