FIG 5.

Amino acid variation between VP7 proteins of rotaviruses circulating in Nashville, TN, since 2005 and those of vaccine strains. (Upper left) Surface representation of a rotavirus virion, with VP4 colored red and VP7 colored yellow (PDB accession no. 4V7Q) (9). The boxed area shows an enlarged RRV VP7 trimer colored light gray, with known antigenic epitopes colored red (7-1A), khaki (7-1b), and purple (7-2) (PDB accession no. 3FMG) (96). Positions at which all derived VP7 amino acid sequences of a particular G type from the VUMC NVSN collection (2005 to 2013) differ from those of the indicated VP7 vaccine component(s) are colored cyan. The word “all” refers to all VP7 components of RV1 (G1) and RV5 (G1, G2, G3, G4, and bovine G6).