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. 2018 Dec 4;9:1384. doi: 10.3389/fphar.2018.01384

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Copyright © 2018 Sang, Gu, Pan, Zhang, Rong, Wu, Xia, Li, Ge, Zhang and Chu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of melatonin on inflammation and apoptosis on day 14. (A) Representative myocardial pathological changes on day 14 (n = 5 in each group, three sections per heart were examined). (B–D) Expression of proinflammatory cytokines, apoptosis-related protein Bax, Bcl-2, cleaved caspase-3, and cleaved caspase 9 in the heart on day 14 (n = 5 in each group). (E) Double staining for DAPI (blue) and TUNEL (green) of sections from myocardium on day 14, scale bar = 50 μm (n = 5 in each group). ^∗P < 0.05 versus the normal group, ^#P < 0.05 versus the CVB3 group, ∆P < 0.05 versus the CVB3 + MLT group.