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. 2018 Dec 4;11:420. doi: 10.3389/fnmol.2018.00420

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Copyright © 2018 Luo, Yu, Cai, Zhang, Jiao, Yu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of the hM3Dq receptors in PBN neurons and activation of neurons with CNO. (A) Coronal section showing the injection sites of AAV-hSyn-hM3Dq-EGFP or AAV-hSyn-EGFP in the PBN. (B) Outline of hM3Dq-EGFP in PBN nucleus. (C) Expressions of hM3Dq receptors in PBN from each case are outlined in the propofol group (n = 8) and the isoflurane group (n = 8). (D) c-Fos expression in PBN neurons after hM3Dq rats received CNO or saline i.p. injection. Three rats for each group (2–4 sections per rat). Bar = 100 μm. (E) Mean number of c-Fos positive cells in PBN nucleus. Data are described as mean ± SEM. c-Fos expression in PBN neurons with CNO pretreatment was significantly higher than in the saline pretreatment group (p < 0.0001, unpaired t-test). LPB, lateral parabrachial nucleus; SCP, superior cerebellar peduncle; MPB, medial parabrachial nucleus.