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. 2018 Dec 4;11:420. doi: 10.3389/fnmol.2018.00420

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Copyright © 2018 Luo, Yu, Cai, Zhang, Jiao, Yu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EEG changes under PBN activation in isoflurane anesthesia. (A) Timeline for EEG recording in isoflurane anesthesia. (B) Representative EEG traces during anesthesia and emergence period in hM3Dq rats pretreated with CNO or saline. (C,D) Spectrograms of EEG power during isoflurane anesthesia and emergence period after delivery of saline (C) or CNO (D) i.p. 0 on the time axis indicates the cession of isoflurane. (E) In the isoflurane anesthesia period, EEG traces 5 min before cessation of anesthetic were compared. No significant difference was found between CNO and saline use in any of the frequency bands quantified (F_4,50 = 0.4886, p = 0.7441, two-way ANOVA). (F) In the recovery period, power spectrum analysis was conducted on data from isoflurane inhalation stop to 5 min after that. CNO i.p. injection in hM3Dq rats, compared to the hM3Dq-saline group, shows a significant decrease in δ power (1–4 Hz). All summary graphs show mean ± SEM (n = 6); ^∗p < 0.05; Bonferroni’s post hoc test after two-way ANOVA.