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. 2018 Nov 28;145(23):dev159889. doi: 10.1242/dev.159889

Fig. 1.

Fig. 1.

Wdr5 depletion alters LR patterning in Xenopus tropicalis. (A,B) Percentage of embryos that have abnormal pitx2c (A) or dand5 (B) expression. Embryos were injected at the one-cell stage, or in one cell at the two-cell stage, with wdr5 MO. Absent, signal absent on both sides; bilateral, signal present on both sides; L, left; R, right; Reduced: signal reduced on both sides. (C-G) Percentage of embryos that have abnormal pitx2c expression. Embryos were injected at the one-cell stage with scrambled MO (C); wdr5 MO, wdr5 MO+human WDR5-3xGFP, scrambled MO injected on the right or left side of embryos (D); second wdr5 MO (E); wdr5 MO, wdr5 MO+K7Q-WDR5-3xGFP or K7Q-WDR5-3xGFP (F); or wdr5 MO and wdr5 MO+human 26-334-3xGFP (G). Experiments were repeated three times. ‘n’=number of embryos. ★P<0.05, ★★P<0.005 and ★★★P<0.0005.