Figure 4.

Outlier-Detection Benchmark

The proportion of simulated outliers among reported outliers (precision) plotted against the proportion of reported simulated outliers among all simulated outliers (recall) for increasing p values up to FDR < 0.05 (OUTRIDER) or decreasing absolute Z scores (PCA and PEER). Plots are provided for four simulated amplitudes (by row with simulated absolute Z scores of 2, 3, 4, and 6 from top to bottom) and for three simulation scenarios (by column from left to right: aberrantly high and low counts, aberrantly high counts, and aberrantly low counts). The read counts were controlled for gene covariation with OUTRIDER (green), PCA (orange), or PEER (blue). The ranking of outliers was bootstrapped to yield 95% confidence bands.