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. 2018 Dec 4;9:1671. doi: 10.3389/fphys.2018.01671

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Copyright © 2018 Zheng, You, Hua, Wu, Liu, Chen, Zhang, Wei, Li, Luo, Zeng, Liu, Luo, Zhang, Feng, Hu, Pandol and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chlorophyllin treatment increases MMP/TIMP ratio, which may promote fibrosis resolution. (A) Reverse transcription coupled quantitated PCR analysis (RT-qPCR) analysis was used to quantitate liver fibrosis, shown the mRNA levels of alpha-smooth actin, type-I collagen, type-III collagen, and transforming growth factor beta-1. (B) Western blot analysis of liver fibrosis by where alpha-smooth muscle actin and fibronectin were examined. (C) Western blot analysis of matrix metalloproteinases (MMP9 and MMP13) and corresponding tissue inhibitors of matrix metalloproteinases (TIMP1, TIMP2). (D) Ratio of MMP9/TIMP1 and MMP13/TIMP1 based on densitometry data. ^∗P < 0.05, ^∗∗P < 0.01. ^∗/∗∗ Comparisons have been indicated with bars. Data show Means ± SEM.