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. 2018 Dec 4;9:1671. doi: 10.3389/fphys.2018.01671

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Copyright © 2018 Zheng, You, Hua, Wu, Liu, Chen, Zhang, Wei, Li, Luo, Zeng, Liu, Luo, Zhang, Feng, Hu, Pandol and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysbiosis occurring in the liver fibrosis can be rebalanced by oral administration of chlorophyllin for eubiosis. (A) Sketch of the experimental design. (B–E) The fecal microbiome of mice as described in Figure 1 was measured via 16S rDNA-qPCR analysis. Relative abundance of Firmicutes and Bacteroidetes in the three conditions was shown and related to endotoxin in plasma, consequently reduced hepatic inflammation and fibrogenesis. (F–H) Acute impact of oral administration of chlorophyllin on the gut microbiota. Liver fibrotic mice received two doses of chlorophyllin through oral gavage, at 5 and 25 μg/g, respectively. Feces were collected at the indicated time points for 16S rDNA-qPCR analysis. ^∗P < 0.05, ^∗∗P < 0.01. ^∗/∗∗ Comparisons have been indicated with bars. Data show Means ± SEM.