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Activity dependent PSD translocation and CaMKIIα dendritic translation. Synaptic activity leads to Ca2+ influx. Subsequent Ca2+/CaM binding to CaMKIIα and β induce F-actin dissociation, translocation to the PSD and autophosphorylation at T286 and T287 in α and β isoforms, respectively. Calcium entry also enhances local CaMKIIα mRNA translation.
