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. 2018 Dec 4;9:2817. doi: 10.3389/fimmu.2018.02817

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Copyright © 2018 Rohani, Dimitrova, Beppu, Wang, Jefferies and Parks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MMP10 promotes expression of negative regulators of Tlr7 signaling. RNA was isolated from the back skin from untreated (control) mice and wildtype and Mmp10^−/− mice treated with the 1-hit or 2-hit model. Levels of mRNAs for Tnfaip3, Irak3, and Inpp5d were measured by qPCR and normalized to Hprt and Gapdh, n = 7–10 mice per group from two independent experiments. Data are presented as fold increase compared to untreated wildtype control mice. (p ≤ 0.05: ^*WT-Q vs. WT-QQ and Mmp10^−/−-Q vs. Mmp10^−/−-QQ;WT-Q vs. Mmp10^−/−-Q and WT-QQ vs Mmp10^−/−-QQ; ^****p ≤ 0.0001).