Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 4;9:2817. doi: 10.3389/fimmu.2018.02817

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Rohani, Dimitrova, Beppu, Wang, Jefferies and Parks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Hypo-responsiveness of macrophages in culture to repeated TLR7 stimulation is mediated by MMP10. Wildtype and Mmp10^−/− BMDM were stimulated with IMQ for the 1-hit (Q) or 2-hit model. (A,B) mRNA expression levels were quantified by qPCR and normalized to Hprt. Data are normalized to unstimulated wildtype control cells. (C) IL10 was measured in supernatant from cells using ELISA, data are representative of 3 individual experiments (n = 3). (^**p ≤ 0.01: WT-Q vs WT-QQ and ^****p ≤ 0.0001: Mmp10^−/−Q vs. Mmp10^−/−QQ;p ≤ 0.01: WT-QQ vs Mmp10^−/−QQ).