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. 2018 Dec 4;9:735. doi: 10.3389/fendo.2018.00735

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Copyright © 2018 Kim, Jang, Choi, Park and Cho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Improved phenotypes in post-pubertal PCOS model. The post-pubertal (42-day-old) female rats were subcutaneously injected daily with DHEA for up to 20 days. Rats in the sham group were injected with sesame oil without DHEA. (A) Change in body weight after DHEA injection. (B,D) Change in ovary weight (B) and uterus weight (D) after DHEA injection. (C,E) Change in appearance of ovaries (C) and uteri (E) after DHEA injection. (F,G) Paraffin sections from sham (upper panel) and DHEA groups (lower panel) were stained H&E dye. Scale bars in (C,E,F,G) = 500 μm. Mann Whitney U test; ^#p < 0.05 and ^##p < 0.01 vs. Sham group.