Table 1.
Comparison of characters in DHEA-induced PCOS model of pre-pubertal rats.
| Period of DHEA treatment(day after birth) | Mean body weight on end day (g) | Ratio (%) of rats with irregular estrus cycles (numbers) | Mean ovary weight (mg/each) | Ratio of rats with multi–cystic ovaries (numbers) | Mean uterus weight (g/cm) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sham | DHEA | Sham | DHEA | Sham | DHEA | Sham | DHEA | Sham | DHEA | ||
| Pre–pubertal (60 mg/kg BW, s.c., SD rat) | 21–49 | 197.3 ± 3.4 | 195.8 ± 5.0 | 0 (0/3) | 80 (4/5) | 39.6 ± 1.8 | 26.5 ± 5.6 | 0 (0/3) | 100# (5/5) | – | – |
| 21–42 | 157.7 ± 2.2 | 153.2 ± 2.3 | 0 (0/3) | 80 (4/5) | 30.0 ± 1.2 | 23.3 ± 4.7 | 0 (0/3) | 0 (0/5) | – | – | |
| 21–42 | 172.5 ± 3.8 | 170.8 ± 2.6 | – (N/5) | – (N/5) | 34.2 ± 5.2 | 17.9 ± 1.7# | – (N/5) | – (N/5) | 47.9 ± 10.9 | 61.7 ± 4.3 | |
| 21–42 | 141.4 ± 2.4 | 166.1 ± 2.3# | 0 (0/5) | 80# (4/5) | 33.4 ± 1.6 | 51.4 ± 2.3# | – (N/5) | – (N/5) | 38.1 ± 2.4 | 64.0 ± 7.2# | |
| 21–46 | 148.3 ± 2.0 | 168.0 ± 1.8# | 0 (0/5) | 60 (3/5) | 35.9 ± 2.6 | 52.9 ± 2.7# | – (N/5) | – (N/5) | 41.8 ± 1.2 | 81.3 ± 10.6# | |
| 21–46 | 145.4 ± 4.2 | 157.4 ± 4.5 | 0 (0/5) | 60 (3/5) | 35.3 ± 2.3 | 52.5 ± 2.8# | – (N/5) | – (N/5) | 38.9 ± 1.9 | 59.5 ± 7.5# | |
| Mean | – | – | – | 0 (0/21) | 72## (18/25) | – | – | 0 (0/6) | 50 (5/10) | – | – |
#
p < 0.05 and
##
p < 0.01 vs. Sham group. The “-” and “N”, not be identified.