Table 1.
Differentially regulated fibrosis-related genes in A83-01-treated versus control eMSCs.
| Pro-Fibrotic genes | Fold change log2 |
FDR (<0.01) | Ave Expr | |
|---|---|---|---|---|
| Control | A83-01 | |||
| ELN | 0 | -5.00 | 2.16E-05 | 2.35 |
| GREM1 | 0 | -2.13 | 3.73E-05 | 7.07 |
| CXCR4 | 0 | -4.99 | 4.62E-05 | -0.79 |
| IGF2 | 0 | -2.18 | 7.29E-05 | 4.92 |
| TGFB2 | 0 | -2.30 | 8.00E-05 | 2.77 |
| EDN1 | 0 | -2.84 | 8.15E-05 | 0.05 |
| LRRC17 | 0 | -2.85 | 1.32E-04 | 6.47 |
| MGP | 0 | -4.10 | 1.34E-04 | 3.42 |
| PDGFC | 0 | -1.83 | 1.37E-04 | 6.29 |
| FN1 | 0 | -2.38 | 1.46E-04 | 12.03 |
| MMP2 | 0 | -1.75 | 3.61E-04 | 11.21 |
| COL1A1 | 0 | -1.39 | 4.83E-04 | 14.07 |
| MIR199A2 | 0 | -1.88 | 5.73E-04 | -1.98 |
| TNC | 0 | -2.44 | 7.23E-04 | 9.13 |
| THBS1 | 0 | -2.45 | 9.42E-04 | 10.16 |
| COMP | 0 | -5.57 | 6.77E-04 | -0.94 |
| LOX | 0 | -1.89 | 1.04E-03 | 8.46 |
| PDGFB | 0 | -1.66 | 1.56E-03 | 2.19 |
| NOX4 | 0 | -2.56 | 1.60E-03 | 1.55 |
| CDH2 | 0 | -2.40 | 2.34E-03 | 4.43 |
| CTGF | 0 | -3.36 | 3.99E-03 | 7.56 |
| SPP1 | 0 | -2.50 | 1.48E-02 | 1.28 |
| ACTA2 | 0 | -1.41 | 2.62E-02 | 8.15 |
| SERPINE1 | 0 | -1.33 | 4.35E-02 | 7.55 |
| MMP9 | 0 | -1.27 | 7.55E-02 | -2.35 |
| COL4A2 | 0 | -1.32 | 7.96E-04 | 11.53 |
| COL4A1 | 0 | -1.82 | 6.54E-04 | 10.89 |
| COL11A1 | 0 | -4.02 | 7.33E-05 | 1.91 |
| COL10A1 | 0 | -2.70 | 2.16E-05 | 2.35 |
| CXCL12 | 0 | 1.81 | 1.73E-02 | 7.78 |
| HGF | 0 | 1.21 | 9.64E-03 | 7.86 |
| CCL2 | 0 | 1.67 | 1.63E-02 | 6.49 |
| FGF7 | 0 | 1.66 | 4.52E-04 | 5.74 |
| FBLN1 | 0 | 1.56 | 7.06E-04 | 10.42 |
| VWA1 | 0 | 1.60 | 2.42E-04 | 3.46 |
| CRISPLD2 | 0 | 2.22 | 5.55E-04 | 5.07 |
| IL6 | 0 | 1.81 | 1.20E-02 | 4.45 |
| TGFB3 | 0 | 1.74 | 1.40E-02 | 3.42 |
| MIR155HG | 0 | 2.05 | 7.52E-05 | 2.19 |
| Genes for Latent TGF-β activating enzymes | ||||
| CTSL | 0 | 1.12 | 4.40E-03 | 8.98 |
| CTSW | 0 | 1.70 | 7.26E-02 | -3.86 |
| CAPN6 | 0 | -2.00 | 4.62E-05 | 1.51 |
| CAPNS2 | 0 | -3.98 | 6.04E-04 | -4.41 |
| CAPN9 | 0 | -1.28 | 1.31E-01 | -4.64 |
| THBS1 | 0 | -2.45 | 9.42E-04 | 10.16 |
| MMP3 | 0 | -1.73 | 1.99E-03 | 8.35 |
| MMP10 | 0 | -4.80 | 7.04E-05 | 5.73 |
| MMP2 | 0 | -1.75 | 3.61E-04 | 11.21 |
| MMP15 | 0 | -1.84 | 5.77E-04 | 1.52 |
| ITGB3 | 0 | -1.46 | 1.73E-03 | 4.06 |
| ITGB5 | 0 | -1.59 | 5.68E-06 | 8.80 |
| ITGA1 | 0 | -1.92 | 4.93E-04 | 7.09 |
| ITGA4 | 0 | -1.62 | 5.68E-04 | 6.32 |