Table 2.
Gene profile of MSC potency in A83-01-treated versus control eMSCs.
| MSC potency markers | Fold change log2 (A83-01) | FDR (<0.01) | Ave Expr |
|---|---|---|---|
| TWIST1 | 1.648 | 1.39E-03 | 5.15 |
| TWIST2 | 1.298 | 1.01E-03 | 6.77 |
| JAG1 | 1.758 | 3.81E-04 | 4.82 |
| SLIT2 | 2.055 | 1.89E-05 | 4.33 |
| EFEMP1 | 3.763 | 4.62E-05 | 1.06 |
| TNFRSF21 | 1.235 | 7.36E-03 | 8.42 |
| CDH13 | 1.373 | 1.28E-05 | 7.35 |
| ARHGAP20 | 1.856 | 1.29E-04 | 2.66 |
| MSC positive markers | |||
| THY1/CD90 | 0.05 | 7.59E-01 | 9.38 |
| NT5E/CD73 | 0.65 | 1.61E-02 | 9.01 |
| ENG/CD105 | 0.22 | 1.37E-01 | 7.85 |
| ITGA6/CD49f | 0.67 | 5.66E-02 | 7.38 |
| ALCAM/CD166 | -0.60 | 1.49E-02 | 7.71 |
| CD44 | -0.11 | 4.71E-01 | 10.57 |
| NES | -0.44 | 5.36E-02 | 8.59 |
| FZD9 | -0.70 | 2.00E-01 | -1.10 |
| CD271 | nd | ||
| SSEA-3/4 | nd | ||
| Pluripotency-related genes | |||
| POU5F1B/OCT4B | 0.06 | 9.72E-01 | -4.84 |
| NANOG | nd | ||
| SOX2 | nd | ||
| MSC negative markers | |||
| CD34 | -0.99 | 1.58E-01 | 2.78 |
| PTPRC/CD45 | 0.00 | 9.98E-01 | -1.57 |
| CD14 | 1.74 | 8.31E-03 | 0.62 |
| CD79A | -0.53 | 4.59E-01 | -2.58 |
| HLA-DRA | 0.79 | 4.62E-01 | -5.55 |
| HLA-DRB1 | 0.29 | 7.52E-01 | -4.25 |
| HLA-DRB5 | 0.87 | 3.56E-01 | -4.69 |
| HLA-DRB6 | 1.25 | 2.92E-01 | -5.23 |
nd, none detected.