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. 2018 Dec 18;11(12):2011–2016. doi: 10.18240/ijo.2018.12.22

Table 1. AJCC pathological classification (pTNM).

Primary tumor (pT)
pTX Primary tumor cannot be assessed
pTO No evidence of primary tumor
pT1 Tumor confined to the eye with no optic nerve or choroidal invasion
pT2 Tumor with minimal optic nerve or choroidal invasion
pT2a Tumor superficially invades optic nerve head, or tumor exhibits focal choroidal invasion but does not extend past lamina cribrosa
pT2b Tumor superficially invades optic nerve head and tumor exhibits focal choroidal invasion but does not extend past lamina cribrosa
pT3 Tumor with significant optic nerve and/or choroidal invasion
pT3a Tumor invades optic nerve past lamina cribrosa but not to surgical resection line, or tumor exhibits massive choroidal invasion
pT3b Tumor invades optic nerve past lamina cribrosa but not to surgical resection line and exhibits massive choroidal invasion
pT4 Tumor invades optic nerve to surgical resection line or exhibits extra-ocular extension elsewhere
pT4a Tumor invades optic nerve to resection line, but no extra-ocular extension identified
pT4b Tumor invades optic nerve to resection line, and extra-ocular extension identified
Regional lymph nodes (pN)
pNX Regional lymph nodes cannot be assessed
pNO No regional lymph node metastasis
pN1 Regional lymph node involvement (preauricular, cervical)
pN2 Distant lymph node involvement
Metastasis (pM)
pMX Presence of metastasis cannot be assessed
pM0 No distant metastasis
pM1 Metastasis to sites other than central nervous system
pM1a Single lesion
pM1b Multiple lesions
pM1c Central nervous system metastasis
pM1d Discrete masses without leptomeningeal and/or cerebrospinal fluid involvement
pM1e Leptomeningeal and/or cerebrospinal fluid involvement