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. 2018 Dec 7;24(45):5120–5130. doi: 10.3748/wjg.v24.i45.5120

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Upregulation of microRNA-22 promotes the apoptosis of AR42J cells by suppressing the PI3k/Akt signaling pathway. A: MicroRNA-22 expression level; B: Erb-b2 receptor tyrosine kinase 3 (ErbB3) mRNA expression level; C: ErbB3 protein expression level; D: The apoptosis rate of AR42J cells induced with caerulein (Cae) after transfection; E: Amylase levels in the medium; F: Western blot analysis of the levels of PI3k, p-PI3k, Akt, p-Akt, and apoptosis-associated proteins in AR42J cells. Data were obtained from three independent experiments performed in triplicate and are shown as the mean ± SD. ^NSP > 0.05, ^cP < 0.001 vs miRNA NC or miRNA NC + Cae groups. ErbB3: Erb-b2 receptor tyrosine kinase 3; Cae: Caerulein; miRNA: MicroRNA; miR-22: MicroRNA-22.