Table 2.
Prevalence of high-resolution computed tomography-detected abnormalities in the two humoral primary immunodeficiencies subtypes (CVID and CVID-like), and comparison between the two groups n (%)
| Abnormality | All patients n = 52 | CVID n = 38 | CVID-like n = 14 | P-value (CVID vs CVID-like) |
| Airway abnormalities | ||||
| Bronchiectasis | 36 (69.2) | 27 (71) | 9 (64.3) | 0.8964 |
| Airway wall thickening | 37 (71.2) | 27 (71) | 10 (71.4) | 0.7501 |
| Tree-in-bud | 10 (19.2) | 6 (15.8) | 4 (28.6) | 0.8464 |
| Mucus plugging | 23 (44.2) | 16 (42.1) | 7 (50) | 0.8888 |
| Air trapping1 | 16 (50) | 12 (52.2) | 4 (44.4) | 0.8557 |
| Parenchymal-interstitial abnormalities | ||||
| Consolidation | 14 (26.9) | 11 (28.9) | 3 (21.4) | 0.8495 |
| Ground-glass opacity | 13 (25) | 12 (31.6) | 1 (7.1) | 0.1487 |
| Nodules | 26 (50) | 19 (50) | 7 (50) | 1 |
| Linear and/or irregular opacities | 12 (23.1) | 12 (31.6) | 0 (0)a | 0.0427 |
| Bullae/cysts | 5 (9.6) | 5 (13.2) | 0 (0) | 0.3695 |
a
P <0.05.
1
Values are calculated on the 32 patients (23 CVID + 9 CVID-like) for whom additional expiratory scan was acquired. Chi-square test: CVID vs CVID-like patients; CVID: Common variable immunodeficiency disorders; CVID-like: Including isolated IgG subclass deficiency and selective IgA deficiency.