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Functional NHR-49 and MDT-15 are required to promote skn-1 transcriptional activity. (A) Relative skn-1 mRNA expression was quantified in nhr-49(ok2165) and brap-2(ok1492);nhr-49(ok2165) mutant strains using qPCR. The worms displayed a reduction of skn-1c in the double mutant to wild type levels. P < 0.001***.
