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. 2018 Oct 8;8(12):3857–3863. doi: 10.1534/g3.118.200727

Figure 6.

Figure 6

Proposed model of NHR-49 in the regulation of phase II detoxification gene gst-4. The induction of oxidative stress in brap-2(ok1492) mutant worms activates PMK, which then phosphorylates SKN-1 for nuclear translocation. SKN-1 then binds to NHR-49/MDT-15 in the nucleus to induce gst-4 expression. This complex can also create a feed-forward loop through skn-1c promoter binding to up regulate its own transcription, thereby enhancing both the SKN-1C response to oxidative stress and its target genes.