Fig. 5.

Pathways with ancestry-enriched SNP genes in functional categories of interest. These results highlight examples of specific health-related functions and pathways that have been shaped by genetic ancestry in the four admixed Latin American populations. For each functional category, a pathway schematic is shown, indicating the pathway genes and their roles, along with meta-analysis results and observed versus expected SNP frequencies for each population. a Leishmaniasis, an example of a disease and health related pathway. b Cytochrome P450 drug metabolism, an example of a metabolism related pathway. c Jak-STAT signaling pathway, an example of an immune-related pathway