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. 2018 Dec 10;18:1233. doi: 10.1186/s12885-018-5109-8

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Modulation of tumorigenesis in the MMTV-PyVT transgenic model for human luminal breast cancer. (a) Disease-free survival curves for MMTV-PyVT;MD+/+ (n = 15), MMTV-PyVT;MD+/− (n = 16) and MMTV-PyVT;MD−/− (n = 18) mice. Log-rank test P-values are shown. (b) Average age at the appearance of the first palpable tumor. (c) Average tumor multiplicity at necropsy. (d) Tumor growth plot graphing average diameter size (in mm) versus weeks after first appearance. (e) Average age at end point. (f) Average amount of lung macro-metastatic foci (left panel). Average amount of lung micro-metastatic foci (right panel). * = p < 0.05, **p < 0.01