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. 2018 Dec 11;22:336. doi: 10.1186/s13054-018-2277-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Associations between the rs805305 SNP of the dimethylarginine dimethylaminohydrolase (DDAH)2 promoter region and DDAH activity and outcome in septic shock. a Lower DDAH activity is associated with improved outcome in septic shock. Asymmetric dimethylarginine (ADMA):symmetric dimethylarginine (SDMA) ratio was employed as a marker of DDAH activity. Black line - patients with the lowest activity, dotted grey line - 2nd quartile, dashed grey line - 3rd Quartile, solid grey line – highest-activity quartile. The rs805305 SNP of the promoter region of the DDAH2 gene was sequenced in 284 participants in the VANISH trial. b Kaplan-Meier analysis of the impact of rs805305 SNP on 28-day survival in septic shock. The presence of the rare G:G homozygote (13.9%) was associated with improved survival compared to the common C:C homozygote (44.7), p = 0.02. Mean Sequential Organ Failure Assessment (SOFA) score (c) and shock duration (d) were lower in patients expressing the less common G:G genotype than the common C:C expression pattern, p = 0.04 and p = 0.02, respectively (analysis of variance)