Table 3.

Rab proteins involved in HCV morphogenesis.

Rab	Physiological roles	References	Role for HCV	References
Rab18	LD-associated; promotes growth of LDs, tethering of LDs to cytoplasmic site of ER Involved in ER-Golgi trafficking ER associated; regulates ER dynamics Positive modulator of autophagy and proteostasis Regulates Cholesterol-dependent association of ApoB100 with LDs in hepatocytes Regulates hepatic stellate cell activation Impairs secretory granule transport in neuroendocrine cells Regulates lipolysis and lipogenesis in adipocytes	Xu et al., 2018 Ozeki et al., 2005 Dejgaard et al., 2008 Gerondopoulos et al., 2014 Feldmann et al., 2017 Makino et al., 2016 O'Mahony et al., 2015 Vazquez-Martinez et al., 2007 Pulido et al., 2011	Recruitment of the HCV Core protein to the LDs Binds NS5A; recruitment of LDs to sites of replication	Dansako et al., 2014 Salloum et al., 2013
Rab32	ER- and mitochondria-associated; functions as cAMP-dependent protein kinase (PKA)-anchoring protein (AKAP); controls MAM properties Regulates intracellular lipid accumulation and lipolysis in hepatocytes via adipose triglyceride lipase (ATGL)	Alto et al., 2002 Bui et al., 2010 Li et al., 2016	Interaction of GDP-Rab32 with HCV Core; directing HCV Core toward ER-derived structures in perinuclear region	Pham et al., 2017
	Post-Golgi trafficking of melanosomal enzymes in mice AKAP-dependent melanosome transport in Xenopus melanophores	Wasmeier et al., 2006 Park et al., 2007
	Phagosome maturation in HeLa and COS cells Regulates lipid biosynthesis and activation of autophagy during reprogramming in iPSCs Regulates intracellular lipid accumulation	Hirota and Tanaka, 2009 Pei et al., 2015 Li et al., 2016
	Involved in brain inflammation Regulates late endosomal transport and sorting of LRRK2 (leucine-rich repeat kinase 2)	Liang et al., 2012 Waschbüsch et al., 2014