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Small interfering RNA (siRNA) transfection of progesterone receptor (PR) significantly attenuated cadmium-induced proliferation of ovarian cancer cell lines. Proliferation of (A) OVCAR3 and (B) SKOV3 cells were assayed by bromodeoxyuridine after cell treatement with CdCl2(100, 10, and 1 nM) and progesteron (100 nM). Asteriscks show significant differences between cells in the presence of siRNA transfection and without siRNA (*P< 0.05, **P< 0.01). P, Progesterone; CC, CdCl2.
