Table 1.
Interventions included in the model by population.
| Strategy | Duration (a) | |
|---|---|---|
| Elective total hip replacement (eTHR) | ||
| None | No prophylaxis | Not applicable |
| Mechanical only | AES (above-knee) AES (length unspecified) |
7 days10 days |
| IPCD (length unspecified) | 8 days | |
| Foot pump | 7 days | |
| Foot pump + AES |
7 days | |
| Pharmacological only | LMWH [standard dose (b); standard duration] | 14 days |
| LMWH [standard dose (b); extended duration] | 33 days | |
| Dabigatran (c) | 32 days | |
| Rivaroxaban (d) | 35 days | |
| Apixaban (e) | 32 days | |
| Aspirin (f; low dose, standard duration) | 7 days | |
| LMWH [standard dose(b), standard duration] followed by aspirin (low dose, extended duration) | 10 days (LMWH) followed by 28 days (aspirin) | |
| Combination (Pharmacological + mechanical) | LMWH [standard dose (b); standard duration] + AES | 14 days (LMWH) +10 days (AES) + |
| LMWH [standard dose (b); extended duration] + AES | 33 days (LMWH) + 10 days (AES) | |
| Fondaparinux (g) + AES | 8 days (fondaparinux) 10 days (AES) | |
| Elective total knee replacement (eTKR) | ||
| None | No prophylaxis | Not applicable |
| Mechanical only | AES (length unspecified) | 11 days |
| IPCD (length unspecified) | 6 days | |
| Foot pump | 4 days | |
| Foot pump + AES |
4 days+ 11 days | |
| Pharmacological only | LMWH [standard dose (b); standard duration] | 10 days |
| LMWH [standard dose (b); extended duration] | 30 days | |
| Dabigatran (h) | 11 days | |
| Rivaroxaban (d) | 13 days | |
| Apixaban (e) | 12 days | |
| Aspirin (f; low dose, standard duration) | 14 days | |
| Combination (Pharmacological + mechanical) | LMWH [standard dose (b); standard duration] + AES | 10 days |
| Fondaparinux (g) + AES | 11 days | |
AES, anti-embolism stockings; IPCD, intermittent pneumatic compressions device; LMWH, low molecular weight heparin.
a Average dose and duration based on the randomized controlled trials identified in the systematic review and network meta-analysis.
b LMWH standard prophylactic dose included enoxaparin sodium 40 mg once daily, Dalteparin sodium 5,000 iu once daily and tinzaparin sodium 4,500 iu once daily.
c Dabigatran dose for THR: For Adult 18–74 years, 110 mg, to be taken 1–4 h after surgery, followed by 220 mg once daily. For Adult 75 years and over: 75 mg, to be taken 1–4 h after surgery, followed by 150 mg once daily to be taken 12–24 h after initial dose.
d Rivaroxaban dose: 10 mg once daily.
e apixaban dose: 2.5 mg twice daily.
f aspirin dose 75 – 150 mg once daily.
g fondaparinux dose: 2.5 mg once daily.
h dabigatran dose for TKR: For Adult 18–74 years: 110 mg, to be taken 1–4 h after surgery, followed by 150 mg once daily, to be taken 12–24 h after initial dose. For Adult 75 years and over: 75 mg, to be taken 1–4 h after surgery, followed by 150 mg once daily, to be taken 12–24 h after initial dose.