Table 11.
Cost breakdown for each prophylaxis strategy per person–eTKR population.
| Intervention | Prophylaxis costs | VTE costs (95% CI) | All Bleeding costs (95% CI) | CTEPH costs (95% CI) | PTS costs (95% CI) | Post-amputation costs (95% CI) | Total costs (a) (95% CI) |
|---|---|---|---|---|---|---|---|
| LMWH (std,std) + AES | £142 | £6 (£5 to £6) |
£93 (£32 to £260) |
£13 (£10 to £15) |
£67 (£52 to £99) |
£101 (£69 to £142) |
£448 (£364 to £613) |
| Fondaparinux+ AES | £128 | £11 (£3 to £26) |
£671 (£140 to £2,769) |
£27 (£7 to £72) |
£67 (£25 to £139) |
£0.00 (£0.00 to £0.00) |
£904 (£358 to £3,016) |
| Foot pump + AES | £91 | £8 (£4 to £13) |
£109 (£30 to £371) |
£17 (£8 to £33) |
£91 (£46 to £165) |
£0.00 (£0.00 to £0.00) |
£315 (£208 to £590) |
| IPCD | £42 | £21 (£0.9 to £177) |
£109 (£30 to £371) |
£45 (£0.001 to £448) |
£116 (£31 to £337) |
£0.00 (£0.00 to £0.00) |
£333 (£133 to £1,246) |
| Foot pump | £60 | £4 (£0.8 to £10) |
£109 (£30 to £371) |
£8 (£1.0 to £25) |
£40 (£7 to £118) |
£0.00 (£0.00 to £0.00) |
£219 (£119 to £473) |
| AES | £31 | £27 (£2 to £203) |
£109 (£30 to £371) |
£59 (£0.2 to £485) |
£161 (£66 to £401) |
£0.00 (£0.00 to £0.00) |
£387 (£167 to £1,397) |
| LMWH (std,std) | £111 | £21 (£0.4 to £231) |
£93 (£32 to £260) |
£49 (£0.001 to £572) |
£67 (£14.5 to £328) |
£101 (£69 to £142) |
£468 (£287 to £1,563) |
| LMWH (std,extd) | £356 | £9 (£0.2 to £50) |
£107 (£21 to £511) |
£19 (£0.00 to £130) |
£46 (£8 to £137) |
£103 (£68 to £150) |
£666 (£508 to £1,302) |
| Aspirin | £0.49 | £6 (£2 to £14) |
£92 (£70 to £130) |
£14 (£3 to £36) |
£74 (£21 to £178) |
£0.00 (£0.00 to £0.00) |
£187 (£118 to £304) |
| Dabigatran | £34 | £51 (£0.4 to £640) |
£106 (£32 to £34) |
£111 (£0.002 to £1,322) |
£104 (£14 to £867) |
£0.00 (£0.00 to £0.00) |
£406 (£100 to £2,987) |
| Apixaban | £23 | £44 (£0.2 to £564) |
£80 (£23 to £254) |
£97 (£0.002 to £1,157) |
£79 (£8 to £753) |
£0.00 (£0.00 to £0.00) |
£322 (£69 to £2,624) |
| Rivaroxaban | £25 | £16 (£0.16 to £162) |
£139 (£38 to £470) |
£37 (£0.00 to £388) |
£39 (£6 to £214) |
£0.00 (£0.00 to £0.00) |
£256 (£82 to £1,206) |
| No prophylaxis | £0 | £44 (£2 to £429) |
£109 (£30 to £371) |
£97 (£0.05 to £962) |
£203 (£64 to £701) |
£0.00 (£0.00 to £0.00) |
£453 (£137 to £2,281) |
AES, anti-embolism stockings; eTKR, elective total hip replacement; extd, extended; IPCD, intermittent pneumatic compression devices; LMWH, low molecular weight heparin; std, standard; VTE, venous thromboembolism; CTEPH, chronic thromboembolic pulmonary hypertension; PTS, post thrombotic syndrome. (a) May not exactly equal the sum of the components due to rounding.