Table 9.
Cost breakdown for each prophylaxis strategy per person–eTHR population.
| Intervention | Prophylaxis costs | VTE costs (95% CI) | All Bleeding costs (95% CI) | CTEPH costs (95% CI) | PTS costs (95% CI) | Post-amputation costs (95% CI) | Total costs (a) (95% CI) |
|---|---|---|---|---|---|---|---|
| LMWH (std,std) + AES | £169 | £11 (£10 to £11) |
£210 (£72.8 to £554) |
£19 (£15.4 to £23) |
£60 (£52 to £69) |
£20 (£13 to £27) |
£489 (£350 to £833) |
| LMWH (std,extd)+ AES | £419 | £4 (£5.1 to £13) |
£217 (£39 to £847) |
£4.2(£3 to £26) | £32 (£5 to £107) |
£28 (£18 to £39) |
£706 (£509 to £1,376) |
| Fondaparinux+ AES | £115 | £20 (£5.8 to £59) |
£375 (£92 to £1,248) |
£32 (£2 to £144.5) |
£124 (£49 to £254) |
£0.00 (£0.00 to £0.00) |
£665 (£336 to £1,563) |
| Foot pump + AES | £91 | £32 (£7.3 to £103) |
£99 (£23 to £334) |
£60 (£7 to £228) |
£163 (£34 to £456) |
£0.00 (£0.00 to £0.00) |
£445 (£209 to £926) |
| IPCD | £68 | £75 (£11.3 to £327) |
£99 (£23 to £334) |
£129 (£4 to £654.5) |
£371 (£78 to £847) |
£0.00 (£0.00 to £0.00) |
£742 (£255 to £1,968) |
| AES (above knee) | £50 | £112 (£1.6 to £908) |
£99 (£23 to £334) |
£211 (£36 to £1,502) |
£219 (£15 to £1,183) |
£0.00 (£0.00 to £0.00) |
£691 (£119 to £3,765) |
| Foot pump | £60 | £218 (£4.7 to £978) |
£99 (£23 to £334) |
£420 (£3.5 to £1,632) |
£354 (£19 to £1,300) |
£0.00 (£0.00 to £0.00) |
£1,150 (£161 to £4,054) |
| AES | £31 | £19 (£2.5 to £61.7) |
£99 (£23 to £334) |
£30 (£2 to £136) |
£121 (£11 to £498) |
£0.00 (£0.00 to £0.00) |
£299 (£102 to £793) |
| LMWH (std,std) | £138 | £39 (£7.6 to £140) |
£210 (£72.8 to £554) |
£66 (£5 to £311) |
£218 (£47 to £555) |
£20 (£13 to £27) |
£691 (£375 to £1,413) |
| LMWH (std,extd) | £387 | £17 (£2.4 to £54.7) |
£217 (£39 to £847) |
£12 (£0.1 to £87) |
£181 (£21 to £551) |
£28 (£18 to £39) |
£845 (£528 to £1,582) |
| Aspirin (std duration) | £0.24 | £374 (£7.2 to £989) |
£98 (£82 to £119) |
£702 (£8 to £1,687) |
£512 (£34 to £1,322) |
£000 (£000 to £000) |
£1,687 (£157 to £4,034) |
| LMWH (std, std) + Aspirin | £115 | £1.4 (£2 to £9) |
£163 (£11 to £1,225) |
£3 (£0 to £18) |
£7.5 (£0.01 to £54) |
£20 (£13 to £27) |
£311 (£148 to £1,437) |
| Dabigatran | £80 | £55.6 (£7.5 to £227) |
£316 (£75.5 to £1,048) |
£93 (£4 to £487) |
£305 (£42 to £795) |
£0.00 (£0.00 to £0.00) |
£849 (£319 to £1,957) |
| Apixaban | £59 | £23.5 (£1.5 to £132.6) |
£298 (£56.5 to £1,139) |
£53 (£1 to £321) |
£63 (£6.5 to £270) |
£0.00 (£0.00 to £0.00) |
£497 (£163 to £1,588) |
| Rivaroxaban | £74 | £27 (£3.4 to £105) |
£265 (£58.6 to £907) |
£34 (£0.4 to £225) |
£206 (£28 to £629) |
£0.00 (£0.00 to £0.00) |
£606 (£227 to £1,452) |
| No prophylaxis | £0 | £115 (£26 to £416) |
£99 (£23 to £334) |
£213 (£24 to £810) |
£481 (£140 to £957) |
£0.00 (£0.00 to £0.00) |
£908 (£297 to £2,185) |
a AES, anti-embolism stockings; CI, confidence interval; eTHR, elective total hip replacement; extd, extended; IPCD, intermittent pneumatic compression devices; LMWH, low molecular weight heparin; std, standard; VTE, venous thromboembolism; CTEPH, chronic thromboembolic pulmonary hypertension; PTS, post thrombotic syndrome. (a) May not exactly equal the sum of the components due to rounding.