Table 1.

Summary of our ALS patients with FUS mutations.

	Mutation	Sex	Age of onset	Site of onset	Phenotype	Region of involvement	Dementia	Duration (mo)	Family history
Patient One	p.G505Wfs*12	Male	14	Bulbar and Lower limbs	UMN and LMN	Four	Mental retardation	≈11	SALS
Patient Two	p.R495X	Male	17	Bulbar	LMN	Four	No	≈21	FALS
Patient Three	p.R495X	Female	46	Upper limbs	LMN	Four	No	≈12	FALS

Disease duration was defined as the time from onset of the disease to death. ALS – amyotrophic lateral sclerosis; FALS – familial amyotrophic lateral sclerosis; SALS – sporadic amyotrophic lateral sclerosis; LMN – lower motor neuron; UMN – upper motor neuron.