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. 2018 Dec 3;9:2766. doi: 10.3389/fimmu.2018.02766

Figure 1.

Figure 1

Clinical presentation of VZV disease in GATA2-haploinsufficient patient (A) An erytematous, vesicular skin rash on the back of patient 1 with GATA2-haploinsufficiency, 4 days after the onset of VZV disease. (B) Targetoid lesions on the left arm of the same patient, 7 days after the onset of illness. (C) A chest X-ray 8 days after the onset of illness, showing diffuse alveolar involvement with a miliary pattern of pulmonary opacities. (D) Histograms showing perforin expression in CD56+CD16+ lymphocytes from patient 1 (gray), patient 2 (black), an individual with heterozygous A91V PRF1 mutation (green), a healthy control (blue) and isotype control (red dotted line) as assessed by intracellular flow cytometry.