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. 2018 Dec 4;9:1432. doi: 10.3389/fphar.2018.01432

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Copyright © 2018 Yao, Yu, Liu, Xu, Li, Meng, Huang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of PSTPIP2 suppresses FLSs inflammatory response. (A) The protein level of PSTPIP2 was analyzed by Western blot in FLSs with PSTPIP2 overexpression. (B) The mRNA level of PSTPIP2 was analyzed by qRT-PCR in FLSs with PSTPIP2 overexpression. (C) The mRNA levels of TNF-α, IL-1β, and IL-6 were analyzed by qRT-PCR in FLSs with PSTPIP2 overexpression. (D) The protein levels of TNF-α, IL-1β, and IL-6 were analyzed by Western blot in FLSs with PSTPIP2 overexpression. (E) The levels of TNF-α, IL-1β, and IL-6 in FLSs supernatants were detected by ELISA. The bands or images in the figure are representative in three independent experiments. Data shown are the mean ± SD from three independent experiments. Each group contains 5 rats. ^##P < 0.01 versus GV230 group; ^∗∗P < 0.01 versus normal group.