Table 1.
In vitro potency of primary mycobacteria growth inhibitor screen hits.
| Compound | Structure | MIC50 (μM)* | MIC90 (μM) | Compound | Structure | MIC50 (μM) | MIC90 (μM) |
|---|---|---|---|---|---|---|---|
| E01 |  |
6.25 | 6.25 | E09 |  |
12.5 | 50 |
| E02 |  |
3 | 50 | E10 |  |
8 | 25 |
| E03 |  |
50 | >100 | E11 |  |
8 | 12.5 |
| E04 |  |
20 | >100 | E12 |  |
12.5 | >100 |
| E05 |  |
8 | 25 | E13 |  |
30 | >100 |
| E06 |  |
25 | >100 | E14 |  |
40 | >100 |
| E07 |  |
1.25 | 6.25 | E15 |  |
20 | 100 |
| E08 |  |
20 | 100 | E16 |  |
0.8 | 25 |
*
Minimum Inhibitory Concentrations (MICs) are defined as drug concentration that inhibit 50% (MIC50) or 90% (MIC90) of growth relative to the drug-free control.