Figure 5.

The model predicts three types of proliferation changes in response to STAT pathway activation. (A) The change in intestinal stem cells (ISCs) in response to activation of the STAT pathway. By elevating CCS, activation of the STAT pathway moves the ISCs rightward. Solid circles show the ISCs before STAT activation; open circles of identical colors show these ISCs after activation of the STAT pathway. Each arrow represents the trajectory of an individual cell following STAT activation. (B–D) Time series simulations of cells before and after STAT activation (dotted line); a cell that remains arrested after activation (B), a cell that begins to proliferate upon activation (C), and a third cell that proliferates faster after activation (D). To see this figure in color, go online.